Subtypes of Post–COVID-19 Condition: A Review of the Emerging Evidence


 Post–COVID-19 condition is a growing health concern and has been associated with more than 200 possible symptoms. The diverse varied ways the presents clinically creates challenges for developing standard diagnostic criteria, systems aiming to provide effective treatment management supports people.
 To support care, decision-makers clinicians understand different clinical presentations of condition, we scanned evidence base examine early approaches being used characterize describe subtypes post–COVID-19 condition. Subtypes can be developed many disease features patient factors, but this report specifically reviewed potential based on symptoms presentation.
 We found that some develop are statistical methods group together patterns These studies beginning reveal severity symptoms, type co-occurrence affecting organ systems.
 Many reported similar previously characterized conditions. In cases, may manifestations those other For example, certain present myalgic encephalomyelitis/chronic fatigue syndrome or pulmonary fibrosis. It uncertain whether share same distinct pathophysiology they benefit from treatments.
 Early comparing variant infection its association emerging, findings currently mixed. Some suggest variants such as Delta Omicron result in presentations, while have not significant differences. Further research assessing between likely needed.
 This review provides implications considerations should emerging further validate proposed subtypes. important improving diagnosis, treatment, With estimates Canada suggesting million people could affected by monitoring ongoing help development tailored treatments, guide planning across country.